Care in Clinical Trials involving Youth 

Bioethics debates on pediatric research often centers on aspects such as assent and parental permission, shared decision-making, data protection, and regulatory issues. However, the complexity and recent years developments of biomedical research also raise profound  philosophical, historical, and socio-anthropological issues. Over less  than a century, health research has undergone major changes due both to technoscientific innovation and sociocultural processes. Among most important transformations are the development of clinical  epidemiology, of evidence-based medicine, and the Cochrane Collaboration; the emergence of the fields of medical humanities and bioethics, as well as international and national guidelines and recommendations; and the steady growth of patient and public involvement’s initiatives. Against this background, CareInTrials explores possible dimensions of care in pediatric research, while examining the different ways in which childhood is understood in everyday practices and relationships within clinical trials.